INSTEM LIMITED
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Cash
£7.8m
-42.3% lowest in 3 filed years
Net assets
£106m
+96.6% highest in 3 filed years
Employees
422
-9.8% lowest in 3 filed years
Profit before tax
£1.5m
+140.1% highest in 3 filed years
Watchouts
Facts from the Companies House register and the latest accounts — not a rating
-
3 officer resignations in last 12 months
Multiple officers have left the board recently — see the People section for who.
Net assets
3-year trend · vs Technology median
Accounts
3-year trend · Δ = latest vs prior filed period · latest reflected 2025-12-31
| Metric | Trend | 2023-12-31 | 2024-12-31 | 2025-12-31 | Δ vs prior |
|---|---|---|---|---|---|
| Turnover | £59,819,000 | £55,269,000 | £64,687,000 | +17% | |
| Operating profit | £297,000 | £2,282,000 | £10,601,000 | +364.5% | |
| Profit before tax | -£9,405,000 | -£3,716,000 | £1,490,000 | +140.1% | |
| Net profit | -£7,918,000 | -£4,643,000 | £1,368,000 | +129.5% | |
| Cash | £11,720,000 | £13,465,000 | £7,763,000 | -42.3% | |
| Total assets less current liabilities | — | £54,992,000 | £166,476,000 | +202.7% | |
| Net assets | £46,415,000 | £53,695,000 | £105,581,000 | +96.6% | |
| Equity | £46,415,000 | £53,695,000 | £105,581,000 | +96.6% | |
| Average employees | 533 | 468 | 422 | -9.8% | |
| Wages | £28,503,000 | £25,638,000 | £23,523,000 | -8.2% | |
| Directors' remuneration | £477,000 | £452,000 | £644,000 | +42.5% |
Values shown as filed in the company's annual accounts. — indicates the figure wasn't present under that line item in that period. The Δ column is the change from the prior filed period as a percentage of |prior|; lines a company doesn't report show —. About these numbers
Ratios
Computed from the line items above — sparklines read oldest → newest
| Ratio | Trend | 2023-12-31 | 2024-12-31 | 2025-12-31 |
|---|---|---|---|---|
| Operating margin | 0.5% | 4.1% | 16.4% | |
| Net margin | -13.2% | -8.4% | 2.1% | |
| Return on capital employed | — | 4.1% | 6.4% | |
| Gearing (liabilities / total assets) | 47.7% | 42.1% | 49.6% | |
| Current ratio | 0.75x | 0.87x | 0.70x | |
| Interest cover | 0.22x | 3.05x | 4.33x |
Margins divide P&L lines by turnover. Gearing is liabilities over total assets. Current ratio is current assets over creditors falling due within one year. Interest cover is operating profit over absolute finance costs. Sector-distribution context coming next.
Name history
Renamed 4 times since incorporation
- INSTEM LIMITED 2023-12-12 → present
- INSTEM PLC 2012-01-13 → 2023-12-12
- INSTEM LIFE SCIENCE SYSTEMS PLC 2010-10-07 → 2012-01-13
- INSTEM LIFE SCIENCE SYSTEMS LIMITED 2010-09-24 → 2010-10-07
- HELIUM MIRACLE 99 LIMITED 2010-02-05 → 2010-09-24
Audit & accounting basis
- Accounting basis
- UK-adopted international accounting standards
- Reporting scope
- Consolidated group
- Auditor
- PKF Littlejohn LLP
- Audit opinion
- Unqualified (clean)
- Going concern
- Affirmed
“In auditing the financial statements, we have concluded that the directors' use of the going concern basis of accounting in the preparation of the financial statements is appropriate. Based on the work we have performed, we have not identified any material uncertainties relating to events or conditions that, individually or collectively, may cast significant doubt on the group's or parent company's ability to continue as a going concern for a period of at least twelve months from when the financial statements are authorised for issue.”
Group structure
- INSTEM LIMITED · parent
- Instem Life Science Systems Limited 100%
- Instem LSS Limited 100%
- Instem LSS (North America) Limited 100%
- Instem LSS (Asia) Limited 100%
- Instem Information Systems (Shanghai) Limited 100%
- Instem Scientific Limited 100%
- Instem Scientific Solutions Limited 100%
- Instem Scientific Inc. 100%
- Instem India Pvt Limited 99.9%
- Instem Clinical Holdings Limited 100%
- Instem Clinical Limited 100%
- Instem Clinical Inc. 100%
- Trimetra Limited 100%
- Perceptive Instruments Limited 100%
- Instem Japan K.K 100%
- Notocord Systems S.A. 100%
- Notocord Inc. 100%
- Leadscope Inc. 100%
- The Edge Software Consultancy Limited 100%
- d-Wise Technologies UK Limited 100%
- Instem Inc 100%
- d-Wise Technologies Inc 100%
- d-Wise Technologies Inc., Morrisville succursale de Genève Branch 100%
- d-Wise Technologies Deutschland GmbH 100%
- Pathology Data Systems AG 100%
- Preclinical Data Systems, Inc. 100%
- Pathology Data Systems Ltd Japan Branch 100%
- Pathology Data Systems AG PRATTELN SUCURSALA CRAIOVA 100%
- Strong Tower Solutions 100%
- Rockstep Solutions Inc 100%
- Rockstep Solutions UK Ltd 100%
- Instem Holdings US, LLC 100%
- Xybion Corporation 100%
- Xybion India Private Ltd 100%
- Services Informatiques Xybion, Inc 100%
- Autoscribe Limited 100%
- Autoscribe Informatics Inc 100%
- Autoscribe Informatics PTY 100%
Significant events
- “In May 2025, we expanded our market share in the Clinical line of business by acquiring Strong Tower Solutions (STS), a US-based provider of information technology solutions and services specializing in the implementation, validation, and annual maintenance and support of statistical computing environments (SCE).”
- “In July 2025, we acquired RockStep Solutions, provider of Climb, a cloud-based software solution for non-GLP preclinical study management and Xybion Corporation, a global provider of preclinical study management software and services.”
- “During the second half of 2025, the Group engaged in significant post-acquisition organizational changes and integration activities, including organisational alignment and cost reductions to realise synergies moving forward.”
Auditor, going-concern and subsidiary information is drawn from the narrative of the latest annual accounts. About these numbers
People
3 active · 20 resigned
| Name | Role | Appointed | Born | Nationality |
|---|---|---|---|---|
| OAKWOOD CORPORATE SECRETARY LIMITED | Corporate Secretary | 2025-10-13 | — | — |
| GUILLAUMOT, Vincent | Director | 2024-02-05 | Feb 1978 | French |
| KRISHNAN, Vikram Venkatesh | Director | 2025-10-13 | Apr 1981 | American |
Show 20 resigned officers
| Name | Role | Appointed | Resigned |
|---|---|---|---|
| GOLDSMITH, Nigel John | Secretary | 2011-11-29 | 2023-11-25 |
| MCLAUCHLAN, James | Secretary | 2010-09-15 | 2011-08-08 |
| SHERWIN, David Michael | Secretary | 2011-08-08 | 2011-11-29 |
| OAKWOOD CORPORATE SECRETARY LIMITED | Corporate Secretary | 2010-02-05 | 2010-09-15 |
| BANDALI, Riaz Amirali | Director | 2021-12-01 | 2023-11-20 |
| BERGER, Marc | Director | 2023-11-20 | 2024-02-05 |
| DOLSON, Mary Ruth | Director | 2023-01-09 | 2023-11-20 |
| FARIAS-EISNER, Anthony Giorgio | Director | 2024-02-05 | 2026-04-20 |
| FLINOIS, Xavier | Director | 2023-11-20 | 2024-02-05 |
| GARE, David | Director | 2010-09-15 | 2023-11-20 |
| GOLDSMITH, Nigel John | Director | 2024-02-05 | 2024-04-19 |
| GOLDSMITH, Nigel John | Director | 2011-11-29 | 2023-11-20 |
| HARRIS, Michael Paul | Director | 2010-02-05 | 2010-09-15 |
| MCGOUN, Michael Frederick | Director | 2010-09-15 | 2023-11-20 |
| MCLAUCHLAN, James | Director | 2010-09-15 | 2011-08-08 |
| REASON, Philip John | Director | 2010-09-15 | 2025-10-13 |
| SENDEROVITZ, Thomas | Director | 2023-11-27 | 2024-02-05 |
| SHERWIN, David Michael | Director | 2010-09-15 | 2023-01-31 |
| THIRUKAILAYANATHAN, Jegan | Director | 2024-04-19 | 2026-02-24 |
| THORNE, Muriel Shona | Director | 2010-02-05 | 2010-09-15 |
Ownership
Persons with significant control
| Name | Kind | Nature of control | Notified | Status |
|---|---|---|---|---|
| Ichor Management Limited | Corporate entity | Shares 75–100%, Voting 75–100%, Appoints directors | 2023-11-20 | Active |
Filing timeline
Last 20 of 184 total filings
Material constitutional events — rename, articles re-file, resolution
- 2025-02-11 RESOLUTIONS Resolution
| Date | Type | Category | Description | |
|---|---|---|---|---|
| 2026-07-26 | AA | accounts | Accounts with accounts type group | |
| 2026-04-20 | CS01 | confirmation-statement | Confirmation statement with updates | |
| 2026-04-20 | TM01 | officers | Termination director company with name termination date | |
| 2026-03-06 | CH01 | officers | Change person director company with change date | |
| 2026-02-26 | TM01 | officers | Termination director company with name termination date | |
| 2025-11-03 | MR01 | mortgage | Mortgage create with deed with charge number charge creation date | |
| 2025-10-22 | AP04 | officers | Appoint corporate secretary company with name date | |
| 2025-10-22 | AP01 | officers | Appoint person director company with name date | |
| 2025-10-22 | TM01 | officers | Termination director company with name termination date | |
| 2025-10-16 | PSC05 | persons-with-significant-control | Change to a person with significant control | |
| 2025-08-20 | SH01 | capital | Capital allotment shares | |
| 2025-08-08 | SH01 | capital | Capital allotment shares | |
| 2025-07-31 | MR01 | mortgage | Mortgage create with deed with charge number charge creation date | |
| 2025-06-19 | AA | accounts | Accounts with accounts type group | |
| 2025-05-29 | SH01 | capital | Capital allotment shares | |
| 2025-02-18 | CS01 | confirmation-statement | Confirmation statement with updates | |
| 2025-02-12 | RP04SH01 | capital | Second filing capital allotment shares | |
| 2025-02-11 | RESOLUTIONS | resolution | Resolution | |
| 2025-02-10 | SH01 | capital | Capital allotment shares | |
| 2025-01-06 | SH01 | capital | Capital allotment shares |
Public-record activity
Raw counts from Companies House — last 12–24 months
- Filings
- 12
- Capital events
- 6
- Officers appointed
- 2
- Officers resigned
- 3
last 12 months
last 24 months
last 12 months
last 12 months
Direct counts from the register. No score, no rating — see the Filing timeline for the underlying events.