INSTEM LIMITED

• ◆

  3 officer resignations in last 12 months

  Multiple officers have left the board recently — see the People section for who.

Values shown as filed in the company's annual accounts. — indicates the figure wasn't present under that line item in that period. About these numbers

• Turnover

  -7.6%

  £59,819,000 → £55,269,000

• Cash

  +14.9%

  £11,720,000 → £13,465,000

• Net assets

  +15.7%

  £46,415,000 → £53,695,000

• Employees

  -12.2%

  533 → 468

• Operating profit

  +668.4%

  £297,000 → £2,282,000

• Profit before tax

  +60.5%

  -£9,405,000 → -£3,716,000

• Wages

  -10.1%

  £28,503,000 → £25,638,000

Each % is (latest − prior) ÷ |prior| for the line item as filed. The comparison is only shown when the latest and prior accounts cover broadly equal-length periods — short or long stubs (typical around incorporation or a year-end change) are suppressed rather than misrepresented. Lines a company doesn't report are omitted. About these numbers

Margins divide P&L lines by turnover. Gearing is liabilities over total assets. Current ratio is current assets over creditors falling due within one year. Interest cover is operating profit over absolute finance costs. Sector-distribution context coming next.

1. INSTEM LIMITED 2023-12-12 → present
2. INSTEM PLC 2012-01-13 → 2023-12-12
3. INSTEM LIFE SCIENCE SYSTEMS PLC 2010-10-07 → 2012-01-13
4. INSTEM LIFE SCIENCE SYSTEMS LIMITED 2010-09-24 → 2010-10-07
5. HELIUM MIRACLE 99 LIMITED 2010-02-05 → 2010-09-24

Accounting basis

IFRS

Reporting scope

Consolidated group

Auditor

PKF Littlejohn LLP

Audit opinion

Unqualified (clean)

Going concern

Affirmed

“After considering the uncertainties described above, the directors have a reasonable expectation that the Group has adequate resources to continue in operational existence for the foreseeable future and as a minimum until 30 June 2026 For these reasons, they continue to adopt the going concern basis in preparing this annual report and accounts.”

Group structure

1. INSTEM LIMITED · parent
   1. Instem Life Science Systems Limited 100% · England and Wales · Holding company
   2. Instem LSS Limited 100% · England and Wales · Software development, sales, sales support and administrative support
   3. Instem LSS (North America) Limited 100% · England and Wales · Sales, sales support and administrative support
   4. Instem LSS (Asia) Limited 100% · Hong Kong · Holding company
   5. Instem Information Systems (Shanghai) Limited 100% · Shanghai, PRC · Sales, sales support and service
   6. Instem Scientific Limited 100% · England and Wales · Leading provider of software solutions for extracting intelligence from R&D related healthcare data
   7. Instem Scientific Solutions Limited 100% · England and Wales · Dormant
   8. Instem Scientific Inc. 100% · USA · Leading provider of software solutions for extracting intelligence from R&D related healthcare data
   9. Instem India Pvt Limited 99.9% · India · Software development
   10. Instem Clinical Holdings Limited 100% · England and Wales · Holding Company
   11. Instem Clinical Limited 100% · England and Wales · Provision of electronic data capture and clinical management solutions to the pharmaceutical industry
   12. Instem Clinical Inc. 100% · USA · Provision of electronic data capture and clinical management solutions to the pharmaceutical industry
   13. Trimetra Limited 100% · England and Wales · Software development and consultancy
   14. Perceptive Instruments Limited 100% · England and Wales · Development, manufacture and supply of software and hardware products for in vitro study data collection and study management in the genetic toxicology, microbiology and immunology markets
   15. Instem Japan K.K 100% · Japan · Sales, sales support and service
   16. Notocord Systems S.A. 100% · France · Software development, sales support and administrative support
   17. Notocord Inc. 100% · USA · Sales, sales support and administrative support
   18. Leadscope Inc. 100% · USA · Leading provider of in-silico safety assessment software
   19. The Edge Software Consultancy Limited 100% · England and Wales · Software development, sales, sales support and consultancy activities
   20. d-Wise Technologies UK Limited 100% · England and Wales · Software development, sales, sales support and consultancy activities on clinical trial analysis
   21. Instem Inc 100% · USA · Holding Company
   22. d-Wise Technologies Inc 100% · USA · Software development, sales, sales support and consultancy activities on clinical trial analysis
   23. d-Wise Technologies Inc., Morrisville succursale de Genève Branch 100% · Switzerland · Software development, sales, sales support and consultancy activities on clinical trial analysis
   24. d-Wise Technologies Deutschland GmbH 100% · Germany · Software development, sales, sales support and consultancy activities on clinical trial analysis
   25. Pathology Data Systems AG 100% · Switzerland · Software development, sales, sales support and provider of regulatory information management software
   26. Preclinical Data Systems, Inc. 100% · USA · Software development
   27. Pathology Data Systems Ltd Japan Branch 100% · Japan · Software development
   28. Pathology Data Systems AG PRATTELN - SUCURSALA CRAIOVA 100% · Romania · Software development

Significant events

• “The Group demonstrated its resilience after it was impacted by a Cyber Incident in January 2024.”
• “In December 2024, Instem acquired Trimetra Limited, a software development and consultancy business based in Liverpool, UK.”
• “Instem Group entered into an agreement to acquire Strong Tower Solutions in May 2025. The acquisition is set to complete after the date of approval of these financial statements.”

Auditor, going-concern and subsidiary information is drawn from the narrative of the latest annual accounts. About these numbers

Filings

14

last 12 months

Capital events

6

last 24 months

Officers appointed

2

last 12 months

Officers resigned

3

last 12 months

Direct counts from the register. No score, no rating — see the Filing timeline for the underlying events.