SILENCE THERAPEUTICS PLC
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Cash
£8.4M
-91.3% lowest in 3 filed years
Net assets
£46M
-56.8% vs 2024
Employees
104
-10.3% lowest in 3 filed years
Profit before tax
-£73M
-61.3% lowest in 3 filed years
Watchouts
Facts from the Companies House register and the latest accounts — not a rating
-
Material uncertainty over going concern
The Group has incurred recurring losses since inception, including net losses of £67.1 million for the year ended 31 December 2025. ... Based on this evaluation, the Group believes that its current cash and cash equivalents and U.S. treasury bills as of 31 December 2025 are sufficient to fund its forecasted operating expenses and capital expenditure requirements into 2028.
-
Going-concern uncertainty disclosed
Net assets
3-year trend · vs Health Care median
Accounts
3-year trend · Δ = latest vs prior filed period · latest reflected 2025-12-31
| Metric | Trend | 2023-12-31 | 2024-12-31 | 2025-12-31 | Δ vs prior |
|---|---|---|---|---|---|
| Turnover | £25,375,000 | £33,833,000 | £423,000 | -98.7% | |
| Operating profit | -£49,504,000 | -£49,033,000 | -£68,955,000 | -40.6% | |
| Profit before tax | -£50,310,000 | -£45,080,000 | -£72,733,000 | -61.3% | |
| Net profit | -£43,267,000 | -£35,242,000 | -£67,092,000 | -90.4% | |
| Cash | £54,031,000 | £96,786,000 | £8,374,000 | -91.3% | |
| Total assets less current liabilities | £76,218,000 | £120,331,000 | £56,374,000 | -53.2% | |
| Net assets | £17,050,000 | £106,946,000 | £46,236,000 | -56.8% | |
| Equity | £17,050,000 | £106,946,000 | £46,236,000 | -56.8% | |
| Average employees | 115 | 116 | 104 | -10.3% | |
| Wages | £15,383,000 | £15,200,000 | £14,578,000 | -4.1% | |
| Directors' remuneration | £553,000 | £800,000 | — | — |
Values shown as filed in the company's annual accounts. — indicates the figure wasn't present under that line item in that period. The Δ column is the change from the prior filed period as a percentage of |prior|; lines a company doesn't report show —. About these numbers
Ratios
Computed from the line items above — sparklines read oldest → newest
| Ratio | Trend | 2023-12-31 | 2024-12-31 | 2025-12-31 |
|---|---|---|---|---|
| Operating margin | -195.1% | -144.9% | — | |
| Net margin | -170.5% | -104.2% | — | |
| Return on capital employed | -65.0% | -40.7% | -122.3% | |
| Gearing (liabilities / total assets) | 81.9% | 33.8% | 52.6% | |
| Current ratio | 4.56x | 3.62x | 2.14x | |
| Interest cover | — | — | -10.76x |
Margins divide P&L lines by turnover. Gearing is liabilities over total assets. Current ratio is current assets over creditors falling due within one year. Interest cover is operating profit over absolute finance costs. Margin ratios are hidden where reported turnover is too small relative to profit to yield a meaningful figure — typical of holding companies whose income is mostly subsidiary dividends rather than trading revenue. Sector-distribution context coming next.
Name history
Renamed 2 times since incorporation
- SILENCE THERAPEUTICS PLC 2007-04-26 → present
- SR PHARMA PLC 1999-06-21 → 2007-04-26
- STANFORD ROOK HOLDINGS PLC 1994-11-18 → 1999-06-21
Audit & accounting basis
- Accounting basis
- IFRS
- Reporting scope
- Consolidated group
- Auditor
- PricewaterhouseCoopers LLP
- Audit opinion
- Unqualified (clean)
- Going concern
- Material uncertainty disclosed
“The Group has incurred recurring losses since inception, including net losses of £67.1 million for the year ended 31 December 2025. ... Based on this evaluation, the Group believes that its current cash and cash equivalents and U.S. treasury bills as of 31 December 2025 are sufficient to fund its forecasted operating expenses and capital expenditure requirements into 2028.”
Group structure
- SILENCE THERAPEUTICS PLC · parent
- Silence Therapeutics GmbH 100%
- Silence Therapeutics (London) Ltd 100%
- Innopeg Ltd 100%
- Silence Therapeutics Inc. 100%
Auditor, going-concern and subsidiary information is drawn from the narrative of the latest annual accounts. About these numbers
People
6 active · 61 resigned
| Name | Role | Appointed | Born | Nationality |
|---|---|---|---|---|
| HELLUMS, Rhonda | Secretary | 2024-01-26 | — | — |
| EDE-GOLIGHTLY, James Lawrence | Director | 2025-12-14 | Aug 1979 | British |
| HELLUMS, Rhonda | Director | 2025-12-18 | Dec 1971 | American |
| LEMUS, Dave | Director | 2018-06-21 | Oct 1962 | American |
| MCINERNEY, Tim | Director | 2025-05-05 | Oct 1960 | American |
| ROSS, Iain Gladstone | Director | 2019-04-25 | Jan 1954 | British |
Show 61 resigned officers
| Name | Role | Appointed | Resigned |
|---|---|---|---|
| DAVIES, Jon Melvyn | Secretary | 1994-11-18 | 2010-02-27 |
| ELLAM, David John | Secretary | 2016-07-18 | 2019-01-09 |
| FREEBORN, Tim | Secretary | 2012-08-02 | 2016-07-19 |
| HERRMANN, Max Stephen | Secretary | 2010-05-14 | 2012-08-02 |
| MURPHY, Sarah | Secretary | 2022-09-28 | 2023-12-22 |
| QUINN, Robert, Dr | Secretary | 2019-01-09 | 2020-12-01 |
| RUSKIN, Barbara, Dr. | Secretary | 2020-12-01 | 2022-09-28 |
| TEMPLE SECRETARIES LIMITED | Corporate Nominee Secretary | 1994-11-18 | 1994-11-18 |
| BOYLE, Eric James | Director | 1994-11-18 | 2004-05-20 |
| CAMPION, Giles Victor, Dr | Director | 2020-06-09 | 2023-07-01 |
| CAMPION, Giles Victor, Dr | Director | 2020-05-19 | 2020-06-09 |
| CARSWELL, John Wilson | Director | 1994-11-18 | 1995-03-01 |
| CHARD, Timothy | Director | 1997-02-21 | 2003-07-20 |
| CHENG, Annie | Director | 2013-05-30 | 2014-09-02 |
| CHRISTELY, Thomas | Director | 2011-09-19 | 2012-02-09 |
| CLANCY, Annette | Director | 2008-07-01 | 2012-08-02 |
| COLLINSON, Stuart John Myles, Dr | Director | 2016-01-18 | 2016-04-05 |
| CURNOCK COOK, Jeremy Lawrence | Director | 2005-07-11 | 2010-01-05 |
| DAVIDSON, Michael, Dr. | Director | 2021-01-06 | 2025-08-11 |
| DAVIES, Jon Melvyn | Director | 1994-11-18 | 2010-02-27 |
| EDE-GOLIGHTLY, James Lawrence | Director | 2019-04-25 | 2025-06-26 |
| ELLAM, David John | Director | 2016-07-18 | 2019-01-09 |
| FREEBORN, Timothy Charles Adrian | Director | 2012-10-08 | 2016-06-17 |
| GEDDES, Duncan, Prof | Director | 2000-08-21 | 2002-05-22 |
| GRAY, Alistair William | Director | 2015-11-12 | 2024-04-30 |
| HAWORTH, Philip | Director | 2010-01-05 | 2011-08-01 |
| HERRMANN, Max Stephen | Director | 2010-05-14 | 2012-08-02 |
| HILL, David | Director | 2003-05-19 | 2004-06-18 |
| JENKINS, Annalisa | Director | 2017-10-16 | 2018-08-20 |
| KARLSSON, Lars Georg Emanuel | Director | 2015-01-08 | 2016-04-05 |
| KENNARD, David Anthony, Dr | Director | 1997-05-12 | 2003-07-17 |
| KHAN, Michael Mohamed Tarik, Dr | Director | 2012-09-18 | 2016-06-17 |
| LAMBERT, John Anthony | Director | 2000-09-18 | 2004-05-20 |
| LANG, Thomas, Dr | Director | 1998-02-10 | 2002-05-21 |
| MACK, David | Director | 2010-01-05 | 2013-06-26 |
| MORTAZAVI, Ali | Director | 2012-08-02 | 2018-06-04 |
| PARKER, Stephen Barry, Dr | Director | 2013-11-18 | 2019-04-25 |
| PATTISON, John, Professor | Director | 1994-11-18 | 1999-08-31 |
| RANDALL, Jeremy Anthony Philip | Director | 2008-07-01 | 2013-11-18 |
| REYNOLDS, Hugh Ronald Peter | Director | 2004-05-20 | 2010-01-05 |
| RICHARDS, Andrew John Mcglashan, Dr | Director | 2016-09-14 | 2019-04-16 |
| RIDDELL, Alastair James, Dr | Director | 2013-11-18 | 2015-09-22 |
| ROMANO, Steven, Dr | Director | 2019-07-29 | 2023-04-01 |
| ROOK, Graham Arthur William, Professor | Director | 1994-11-18 | 2001-09-27 |
| ROSS, Iain Gladstone | Director | 2004-05-28 | 2010-02-27 |
| ROSS, Iain Gladstone | Director | 2003-01-07 | 2003-03-04 |
| ROTHERA, Mark | Director | 2020-09-14 | 2022-02-22 |
| RUGHEIMER, Iain Nils Hessey | Director | 1994-12-19 | 2008-07-01 |
| SEDGWICK, Anthony, Dr | Director | 2012-02-09 | 2012-08-02 |
| SOLOMON, David Horn, Dr | Director | 2018-07-17 | 2019-12-17 |
| STANFORD, Cynthia Ann | Director | 1994-11-18 | 1998-03-25 |
| STANFORD, John Lawson, Dr | Director | 1994-11-18 | 2001-09-27 |
| STURGE, Simon John | Director | 2013-08-21 | 2016-01-18 |
| TOOMAN, Craig | Director | 2022-02-22 | 2025-12-14 |
| TOPPER, James | Director | 2010-01-05 | 2011-07-29 |
| U'PRICHARD, David Charles, Dr | Director | 2005-07-11 | 2011-12-31 |
| VICK, Jeffery Scott | Director | 2007-07-27 | 2008-07-17 |
| WARREN, Simon Oliver Henry | Director | 1994-11-18 | 1998-03-25 |
| WETZEL, Bernd Otto, Dr | Director | 2005-07-11 | 2010-01-05 |
| COMPANY DIRECTORS LIMITED | Corporate Nominee Director | 1994-11-18 | 1994-11-18 |
| TEMPLE SECRETARIES LIMITED | Corporate Nominee Director | 1994-11-18 | 1994-11-18 |
Ownership
Persons with significant control
| Name | Kind | Nature of control | Notified | Status |
|---|---|---|---|---|
| Mr Richard Ian Griffiths | Individual | Shares 25–50% | 2025-08-04 | Active |
| Mr Richard Ian Griffiths | Individual | Shares 25–50% (as firm) | 2017-07-27 | Ceased 2021-11-30 |
Filing timeline
Last 20 of 365 total filings
Material constitutional events — rename, articles re-file, resolution
- 2025-08-04 RESOLUTIONS Resolution
- 2025-08-04 MA Memorandum articles
| Date | Type | Category | Description | |
|---|---|---|---|---|
| 2026-06-21 | AA | accounts | Accounts with accounts type group | |
| 2026-01-09 | AP01 | officers | Appoint person director company with name date | |
| 2026-01-08 | AP01 | officers | Appoint person director company with name date | |
| 2026-01-06 | TM01 | officers | Termination director company with name termination date | |
| 2025-08-20 | SH01 | capital | Capital allotment shares | |
| 2025-08-20 | PSC01 | persons-with-significant-control | Notification of a person with significant control | |
| 2025-08-20 | PSC09 | persons-with-significant-control | Withdrawal of a person with significant control statement | |
| 2025-08-19 | CS01 | confirmation-statement | Confirmation statement with updates | |
| 2025-08-18 | TM01 | officers | Termination director company with name termination date | |
| 2025-08-04 | RESOLUTIONS | resolution | Resolution | |
| 2025-08-04 | MA | incorporation | Memorandum articles | |
| 2025-06-27 | TM01 | officers | Termination director company with name termination date | |
| 2025-05-27 | AA | accounts | Accounts with accounts type group | |
| 2025-05-13 | AP01 | officers | Appoint person director company with name date | |
| 2025-05-12 | SH01 | capital | Capital allotment shares | |
| 2024-12-11 | SH01 | capital | Capital allotment shares | |
| 2024-08-28 | CS01 | confirmation-statement | Confirmation statement with updates | |
| 2024-08-19 | SH01 | capital | Capital allotment shares | |
| 2024-08-16 | SH01 | capital | Capital allotment shares | |
| 2024-08-16 | SH01 | capital | Capital allotment shares |
Public-record activity
Raw counts from Companies House — last 12–24 months
- Filings
- 11
- Capital events
- 6
- Officers appointed
- 2
- Officers resigned
- 2
last 12 months
last 24 months
last 12 months
last 12 months
Direct counts from the register. No score, no rating — see the Filing timeline for the underlying events.