CENTESSA PHARMACEUTICALS PLC
Centessa Pharmaceuticals plc is a public biotechnology company focused on the research and experimental development of novel medicines.
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Cash
£285M
USD 383,221,000
+199.3% vs 2023
Net assets
£299M
USD 401,545,000
+70% vs 2023
Employees
78
-1.3% vs 2023
Profit before tax
-£173M
USD -232,913,000
-32.2% vs 2023
Net assets
2-year trend · vs Health Care median
Accounts
2-year trend · Δ = latest vs prior filed period · latest reflected 2024-12-31
| Metric | Trend | 2023-12-31 | 2024-12-31 | Δ vs prior |
|---|---|---|---|---|
| Turnover | £5,095,925 | £5,095,925 | 0% | |
| Operating profit | -£127,366,895 | -£149,505,503 | -17.4% | |
| Profit before tax | -£130,979,328 | -£173,195,271 | -32.2% | |
| Net profit | -£112,347,561 | -£175,310,083 | -56% | |
| Cash | £95,203,748 | £284,965,051 | +199.3% | |
| Total assets less current liabilities | £238,593,843 | £385,782,272 | +61.7% | |
| Net assets | £175,672,219 | £298,590,869 | +70% | |
| Equity | £175,672,219 | £298,590,869 | +70% | |
| Average employees | 79 | 78 | -1.3% | |
| Wages | £20,306,365 | £21,493,159 | +5.8% | |
| Directors' remuneration | — | — | — |
Figures converted to GBP from USD at 0.744 per USD (Frankfurter spot rate) — hover any figure for the original. — indicates the figure wasn't present under that line item in that period. The Δ column is the change from the prior filed period as a percentage of |prior|; lines a company doesn't report show —. About these numbers
Ratios
Computed from the line items above — sparklines read oldest → newest
| Ratio | Trend | 2023-12-31 | 2024-12-31 |
|---|---|---|---|
| Return on capital employed | -53.4% | -38.8% | |
| Gearing (liabilities / total assets) | 34.4% | 30.4% | |
| Current ratio | 8.00x | 9.25x | |
| Interest cover | -17.29x | -19.93x |
Gearing is liabilities over total assets. Current ratio is current assets over creditors falling due within one year. Interest cover is operating profit over absolute finance costs. Margin ratios are hidden where reported turnover is too small relative to profit to yield a meaningful figure — typical of holding companies whose income is mostly subsidiary dividends rather than trading revenue. Sector-distribution context coming next.
Name history
Renamed 2 times since incorporation
- CENTESSA PHARMACEUTICALS PLC 2021-05-14 → present
- CENTESSA PHARMACEUTICALS LIMITED 2021-02-17 → 2021-05-14
- UNITED MEDICINES BIOPHARMA LIMITED 2020-10-26 → 2021-02-17
Audit & accounting basis
- Accounting basis
- US GAAP
- Reporting scope
- Consolidated group
- Auditor
- KPMG LLP
- Audit opinion
- Unqualified (clean)
- Going concern
- Affirmed
“The directors have prepared the financial statements on the going concern basis as they do not intend to liquidate the Group or the Parent Company or to cease their operations, and as they have concluded that the Group's and the Parent Company's financial position means that this is realistic; they have also concluded that there are no material uncertainties that could have cast significant doubt over their ability to continue as a going concern for at least a year from the date of approval of the financial statements ("the going concern period").”
Group structure
- CENTESSA PHARMACEUTICALS PLC · parent
- Centessa Pharmaceuticals Holdings Inc. 100%
- Centessa Pharmaceuticals (UK) Limited 100%
- Z Factor Limited 100%
- ApcinteX Limited 100%
- Centessa Pharmaceuticals LLC 100%
- Centessa Biosciences Inc formerly known as Palladio Biosciences Inc 100%
Significant events
- “On February 14, 2025, Centessa Pharmaceuticals (UK) Limited ("Centessa"), a wholly-owned subsidiary of Centessa Pharmaceuticals plc (the "Company") entered into a License Agreement (the "License Agreement") with Genmab A/S ("Genmab") pursuant to which Centessa granted Genmab an exclusive worldwide license...”
- “On September 28, 2022 ("Original Complaint"), the Company and certain of its current and former directors were named as defendants in a proposed class action lawsuit filed in the United States District Court for the Central District of California.”
- “On August 2, 2024, Judge Gregory Wood of the United States District Court for the Southern District of New York granted in full a motion to dismiss with leave for the plaintiff to amend within twenty-one days certain statements and no leave to amend other statements and no ability to expand the scope of the claims pleaded in the Amended Complaint.”
Auditor, going-concern and subsidiary information is drawn from the narrative of the latest annual accounts. About these numbers
People
9 active · 6 resigned
| Name | Role | Appointed | Born | Nationality |
|---|---|---|---|---|
| HUSSAIN, Iqbal | Secretary | 2021-04-30 | — | — |
| ACCARDI, Mario Alberto, Dr | Director | 2026-01-01 | Feb 1986 | Italian,British |
| DE RUBERTIS, Francesco | Director | 2020-11-20 | Jan 1970 | Italian |
| GOYAL, Arjun, Dr | Director | 2021-01-29 | Jul 1981 | Australian |
| HEDLEY, Mary Lynne | Director | 2021-02-22 | Aug 1962 | American |
| HUKKELHOVEN, Mathias | Director | 2022-07-01 | Nov 1953 | Dutch |
| KULKARNI, Samarth | Director | 2021-02-22 | Nov 1978 | American |
| STUCKLEY, Carol | Director | 2021-05-17 | Sep 1955 | American |
| ZBAR, Brett, Dr | Director | 2021-01-29 | Aug 1972 | American |
Show 6 resigned officers
| Name | Role | Appointed | Resigned |
|---|---|---|---|
| TAIT, Nicholas Alexander James | Secretary | 2020-10-26 | 2021-04-20 |
| OAKWOOD CORPORATE SECRETARY LIMITED | Corporate Secretary | 2021-04-30 | 2021-06-02 |
| CALIFF, Robert Mckinnon | Director | 2021-02-22 | 2022-02-16 |
| KANTOFF, Aaron | Director | 2021-01-29 | 2022-07-01 |
| LEE, Richard Michael | Director | 2020-10-26 | 2021-01-29 |
| SAHA, Saurabh, Dr | Director | 2021-01-29 | 2026-01-01 |
Ownership
Persons with significant control
| Name | Kind | Nature of control | Notified | Status |
|---|---|---|---|---|
| Mr Richard Michael Lee | Individual | Shares 75–100%, Voting 75–100%, Appoints directors | 2020-10-26 | Ceased 2021-01-29 |
Filing timeline
Last 20 of 255 total filings
| Date | Type | Category | Description | |
|---|---|---|---|---|
| 2026-03-26 | SH01 | capital | Capital allotment shares | |
| 2026-03-13 | SH01 | capital | Capital allotment shares | |
| 2026-03-09 | CS01 | confirmation-statement | Confirmation statement with updates | |
| 2026-03-06 | RP01AP01 | officers | Replacement filing of director appointment with name | |
| 2026-02-13 | CH01 | officers | Change person director company with change date | |
| 2026-02-10 | SH01 | capital | Capital allotment shares | |
| 2026-02-06 | SH01 | capital | Capital allotment shares | |
| 2026-01-29 | SH01 | capital | Capital allotment shares | |
| 2026-01-14 | SH01 | capital | Capital allotment shares | |
| 2026-01-13 | TM01 | officers | Termination director company with name termination date | |
| 2026-01-13 | AP01 | officers | Appoint person director company with name date | |
| 2025-12-18 | SH01 | capital | Capital allotment shares | |
| 2025-12-18 | SH01 | capital | Capital allotment shares | |
| 2025-12-18 | SH01 | capital | Capital allotment shares | |
| 2025-12-16 | SH01 | capital | Capital allotment shares | |
| 2025-12-16 | SH01 | capital | Capital allotment shares | |
| 2025-12-15 | SH01 | capital | Capital allotment shares | |
| 2025-11-28 | SH01 | capital | Capital allotment shares | |
| 2025-11-27 | SH01 | capital | Capital allotment shares | |
| 2025-11-05 | SH01 | capital | Capital allotment shares |
Public-record activity
Raw counts from Companies House — last 12–24 months
- Filings
- 20
- Capital events
- 15
- Officers appointed
- 1
- Officers resigned
- 1
last 12 months
last 24 months
last 12 months
last 12 months
Direct counts from the register. No score, no rating — see the Filing timeline for the underlying events.