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Cash

£285M

USD 383,221,000

+199.3% vs 2023

Net assets

£299M

USD 401,545,000

+70% vs 2023

Employees

78

-1.3% vs 2023

Profit before tax

-£173M

USD -232,913,000

-32.2% vs 2023

Accounts

2-year trend · Δ = latest vs prior filed period · latest reflected 2024-12-31

Metric Trend 2023-12-312024-12-31 Δ vs prior
Turnover £5,095,925£5,095,925 0%
Operating profit -£127,366,895-£149,505,503 -17.4%
Profit before tax -£130,979,328-£173,195,271 -32.2%
Net profit -£112,347,561-£175,310,083 -56%
Cash £95,203,748£284,965,051 +199.3%
Total assets less current liabilities £238,593,843£385,782,272 +61.7%
Net assets £175,672,219£298,590,869 +70%
Equity £175,672,219£298,590,869 +70%
Average employees 7978 -1.3%
Wages £20,306,365£21,493,159 +5.8%
Directors' remuneration

Figures converted to GBP from USD at 0.744 per USD (Frankfurter spot rate) — hover any figure for the original. indicates the figure wasn't present under that line item in that period. The Δ column is the change from the prior filed period as a percentage of |prior|; lines a company doesn't report show . About these numbers

Ratios

Computed from the line items above — sparklines read oldest → newest

Ratio Trend 2023-12-312024-12-31
Return on capital employed -53.4%-38.8%
Gearing (liabilities / total assets) 34.4%30.4%
Current ratio 8.00x9.25x
Interest cover -17.29x-19.93x

Gearing is liabilities over total assets. Current ratio is current assets over creditors falling due within one year. Interest cover is operating profit over absolute finance costs. Margin ratios are hidden where reported turnover is too small relative to profit to yield a meaningful figure — typical of holding companies whose income is mostly subsidiary dividends rather than trading revenue. Sector-distribution context coming next.

Name history

Renamed 2 times since incorporation

  1. CENTESSA PHARMACEUTICALS PLC 2021-05-14 → present
  2. CENTESSA PHARMACEUTICALS LIMITED 2021-02-17 → 2021-05-14
  3. UNITED MEDICINES BIOPHARMA LIMITED 2020-10-26 → 2021-02-17

Audit & accounting basis

Accounting basis
US GAAP
Reporting scope
Consolidated group
Auditor
KPMG LLP
Audit opinion
Unqualified (clean)
Going concern
Affirmed

“The directors have prepared the financial statements on the going concern basis as they do not intend to liquidate the Group or the Parent Company or to cease their operations, and as they have concluded that the Group's and the Parent Company's financial position means that this is realistic; they have also concluded that there are no material uncertainties that could have cast significant doubt over their ability to continue as a going concern for at least a year from the date of approval of the financial statements ("the going concern period").”

Group structure

  1. CENTESSA PHARMACEUTICALS PLC · parent
    1. Centessa Pharmaceuticals Holdings Inc. 100% · USA · Corporate Services
    2. Centessa Pharmaceuticals (UK) Limited 100% · UK · Corporate Services & Research and Development
    3. Z Factor Limited 100% · UK · Research & Development
    4. ApcinteX Limited 100% · UK · Research & Development
    5. Centessa Pharmaceuticals LLC 100% · USA · Corporate Services
    6. Centessa Biosciences Inc formerly known as Palladio Biosciences Inc 100% · USA · Research & Development

Significant events

Auditor, going-concern and subsidiary information is drawn from the narrative of the latest annual accounts. About these numbers

People

9 active · 6 resigned

Name Role Appointed Born Nationality
HUSSAIN, Iqbal Secretary 2021-04-30
ACCARDI, Mario Alberto, Dr Director 2026-01-01 Feb 1986 Italian,British
DE RUBERTIS, Francesco Director 2020-11-20 Jan 1970 Italian
GOYAL, Arjun, Dr Director 2021-01-29 Jul 1981 Australian
HEDLEY, Mary Lynne Director 2021-02-22 Aug 1962 American
HUKKELHOVEN, Mathias Director 2022-07-01 Nov 1953 Dutch
KULKARNI, Samarth Director 2021-02-22 Nov 1978 American
STUCKLEY, Carol Director 2021-05-17 Sep 1955 American
ZBAR, Brett, Dr Director 2021-01-29 Aug 1972 American
Show 6 resigned officers
Name Role Appointed Resigned
TAIT, Nicholas Alexander James Secretary 2020-10-26 2021-04-20
OAKWOOD CORPORATE SECRETARY LIMITED Corporate Secretary 2021-04-30 2021-06-02
CALIFF, Robert Mckinnon Director 2021-02-22 2022-02-16
KANTOFF, Aaron Director 2021-01-29 2022-07-01
LEE, Richard Michael Director 2020-10-26 2021-01-29
SAHA, Saurabh, Dr Director 2021-01-29 2026-01-01

Ownership

Persons with significant control

Name Kind Nature of control Notified Status
Mr Richard Michael Lee Individual Shares 75–100%, Voting 75–100%, Appoints directors 2020-10-26 Ceased 2021-01-29

Filing timeline

Last 20 of 255 total filings

Date Type Category Description
2026-03-26 SH01 capital Capital allotment shares PDF
2026-03-13 SH01 capital Capital allotment shares PDF
2026-03-09 CS01 confirmation-statement Confirmation statement with updates PDF
2026-03-06 RP01AP01 officers Replacement filing of director appointment with name PDF
2026-02-13 CH01 officers Change person director company with change date PDF
2026-02-10 SH01 capital Capital allotment shares PDF
2026-02-06 SH01 capital Capital allotment shares PDF
2026-01-29 SH01 capital Capital allotment shares PDF
2026-01-14 SH01 capital Capital allotment shares PDF
2026-01-13 TM01 officers Termination director company with name termination date PDF
2026-01-13 AP01 officers Appoint person director company with name date PDF
2025-12-18 SH01 capital Capital allotment shares PDF
2025-12-18 SH01 capital Capital allotment shares PDF
2025-12-18 SH01 capital Capital allotment shares PDF
2025-12-16 SH01 capital Capital allotment shares PDF
2025-12-16 SH01 capital Capital allotment shares PDF
2025-12-15 SH01 capital Capital allotment shares PDF
2025-11-28 SH01 capital Capital allotment shares PDF
2025-11-27 SH01 capital Capital allotment shares PDF
2025-11-05 SH01 capital Capital allotment shares PDF

Public-record activity

Raw counts from Companies House — last 12–24 months

Filings
20

last 12 months

Capital events
15

last 24 months

Officers appointed
1

last 12 months

Officers resigned
1

last 12 months

Direct counts from the register. No score, no rating — see the Filing timeline for the underlying events.

Official Companies House page